Nature

Long noncoding RNA HOXA-AS2 functions as an oncogene by binding to EZH2 and suppressing LATS2 in acute myeloid leukemia (AML)

Acute myeloid leukemia (AML) is the most common hematological malignancy in the world. Long noncoding RNAs (lncRNAs) play an important role in the development of physiology and pathology. Many reports ...
Nature

Long non-coding RNA HIF1A-As2 and MYC form a double-positive feedback loop to promote cell proliferation and metastasis in KRAS-driven non-small cell lung cancer

HIF1A-As2 is required for cell proliferation, EMT and tumor metastasis. HIF1A-As2 guides its binding protein DHX9 to stimulate MYC signalling, whereas activated MYC, in turn, could transcriptionally ...