The human glycosylase OGG1 extrudes and excises the oxidized DNA base 8-oxoguanine (8-oxoG) to initiate base excision repair and plays important roles in many pathological conditions such as cancer, ...

A triple helical DNA can control gene expression, help in homologous recombination, induce mutations to facilitate DNA repair mechanisms, suppress oncogene formations, etc. However, the structure and ...

Diagrams: Short section of DNA, 1951 -- Chemical structures of the DNA bases, 1951 -- Covalent bonds of the sugar-phosphate backbone -- Schematic view of a nucleotide -- Mg** ions binding phosphate ...

Left panels: Atomic Force Microscopy images show how circular DNA can shift from a relaxed shape into a tightly twisted form, and how the gene-editing protein Cas9 binds to this coiled DNA (Credit: ...

DNA (deoxyribonucleic acid), the molecular "blueprint" carrying the genetic instructions that influence the growth, development, reproduction and predispositions of individual humans, can undergo ...

They were hardly modest, these two brash young scientists who in 1953 declared to patrons of the Eagle Pub in Cambridge, England, that they had "found the secret of life." But James Watson and Francis ...

A collaborative study by the UTokyo-KI LINK program, headed by Camilla Björkegren from Karolinska Institutet, Kristian Jeppsson and Katsuhiko Shirahige from The University of Tokyo shows that a ...

Scientists uncovered DNA's double helix structure in 1953. James Watson and Francis Crick proposed the model. It explained ...

MSK researchers are shedding new light on G-quadruplexes, a type of secondary DNA structure that can cause DNA replication to stall. The structures are a potential therapeutic target in cancer. Image ...

James D. Watson, the brilliant but controversial American biologist whose 1953 discovery of the structure of DNA, the molecule of heredity, ushered in the age of genetics and provided the foundation ...