Negative feedback is a universal control mechanism that lets a system's output throttle its input. If an engine revs up, negative feedback tapers its power source. But if the engine slows down, it ...

Dysregulated R-loops can cause stalled replication forks and telomere instability. However, how R-loops are recognized and regulated, is still not well understood, particularly at telomeres. In a new ...

The past decade has revolutionized our thinking about regulatory RNAs. Primarily through using next-generation sequencing, it has been recognized that a large part of the genome is transcribed and ...

Physical interactions between distal regulatory elements have a key role in regulating gene expression, but the extent to which these interactions vary between cell types and contribute to ...

CTCF is widely recognized for its essential role in mediating chromatin loops to regulate gene expression, particularly by modulating enhancer-promoter (EP) interactions. However, acute depletion of ...