The MRE11-RAD50-NBS1 (MRN) complex is a central, multifunctional factor in the detection, signaling and nucleolytic processing of DNA double-strand breaks (DSBs). To clarify how human MRN binds ...

Conventional genome editing tools rely on DNA double-strand breaks (DSBs) and host recombination proteins to achieve large insertions, resulting in heterogeneous mixtures of undesirable outcomes. We ...

Long interspersed nuclear element-1 (LINE-1 or L1) is the only active, self-copying genetic element in the human genome—comprising about 17% of the genome. It is commonly called a "jumping gene" or ...

Researchers have revealed the structural mechanisms of a major DNA repair pathway in human cells. The research, published today as a Reviewed Preprint in eLife, is described by the editors as a ...

Human DNA in its natural state inside cells (left) compared to eight hours after being infected with HSV-1 (right). The virus compacts the human genome’s size significantly and moves it towards the ...

Duke University Medical Center-led research has identified a human-specific DNA enhancer that regulates neural progenitor proliferation and cortical size. Small genetic changes in HARE5 amplify a key ...

James Dewey Watson, whose co-discovery of the twisted-ladder structure of DNA in 1953 helped launch a revolution in biology and medicine, died Thursday at age 97. He died in hospice care after a brief ...

Cold sore virus takes over human DNA within just one hour, study finds - Study is first to prove that herpes virus reshapes human genome deliberately ...