The high complexity and diversity of the eukaryotic transcriptome poses significant challenges for the efficient detection of specific transcripts. Conventional targeted RNA-seq methods often require ...
Approximately 80% of pediatric tumors occur in low- and middle-income countries (LMIC), where diagnostic tools essential for treatment decisions are often unavailable or incomplete. Development of ...
Non-redundant transcript sequences were annotated for gene function using essential local alignment search tool (BLAST) software, with a significance threshold set at 1E-5 and other parameters set to ...
Immunology researchers are working to understand complex adaptive immune responses, but meaningful signals are often rare, transient, or difficult to capture across large, sample-limited studies.
Genetic variants that cause rare disorders may remain elusive even after expansive testing, such as exome sequencing. The diagnostic yield of genome sequencing, particularly after a negative ...
Legacy sequencing technologies have, undoubtedly, made comprehensive transcriptome analysis possible and are invaluable for the study of human genetics and mechanisms of diseases. However, legacy ...