Background: Biomarker testing is essential for guiding first-line treatment decisions in metastatic non–small cell lung cancer (mNSCLC). Despite guideline recommendations, real-world testing patterns ...
Ms. Charité Ricker, MS, CGC and Dr. Nadine Tung, MD, FASCO share updates from the new ASCO guideline on selection of germline genetic testing panels in patients with cancer. They discuss highlights on ...
Molecular testing, or molecular diagnostics, refers to a group of tests that look at the genetic material in a specimen. It can detect genetic risk factors for certain diseases or provide evidence of ...
Copy number losses of oncogenes and gains of tumor suppressor genes generate common driver mutations
Cancer driver genes can undergo positive selection for various types of genetic alterations, including gain-of-function or loss-of-function mutations and copy number alterations (CNA). We investigated ...
Single nucleotide substitutions (SNSs) are the major type of somatic variation in tumors 1,2. Even though the absolute majority of the point mutations are neutral 3, there are many examples of ...
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