Pancreatic cancer induces B cell lineage plasticity via Pax5 inhibition to sustain immunosuppression
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor characterized by its ability to create an immunosuppressive tumor microenvironment. Here, using robust 3D co-culture systems, ...
Early embryogenesis features rapid cell cycles that impose substantial replication stress (RS). How RS shapes lineage potential remains unclear. Using mouse embryonic stem cells (ESC) as an inner cell ...
Scientists have uncovered new genetic rules that determine whether the immune system’s “killer” T cells remain powerful long-term defenders or become worn out and ineffective. By building a detailed ...
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